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1

Validation of Kinases as Therapeutic Targets for Cancer Therapy: Alternative Approaches for Assessing Diverse Biological Functions

Thomas Beckers, Mathias Schmidt, Volker Gekeler

Journal:

Chemie Ingenieur Technik

Year:

2002

Language:

english

File:

PDF, 68 KB

english, 2002

2

Characterization of actinomycin-D-resistant CHO cell lines exhibiting a multidrug-resistance phenotype and amplified DNA sequences

Heyke Diddens, Volker Gekeler, Manfred Neumann, Dietrich Niethammer

Journal:

International Journal of Cancer

Year:

1987

Language:

english

File:

PDF, 1.22 MB

english, 1987

3

Computer-controlled discontinuous rotating gel electrophoresis for separation of very large DNA molecules

Volker Gekeler, Stefan Weger, Erich Eichele, Hans Probst

Journal:

Analytical Biochemistry

Year:

1989

Language:

english

File:

PDF, 2.07 MB

english, 1989

4

Superantigen-mediated cellular cytotoxicity is dependent on antigen expression, but independent of the P-glycoprotein multidrug resistance phenotype

Cornelia Zehrer, James Beck, Volker Gekeler, Johannes Ihle, Ursula Holzer, Mikael Dohlsten, Terje Kalland, Dietrich Niethammer, GU¨nther E. Dannecker

Journal:

British Journal of Haematology

Year:

1996

Language:

english

File:

PDF, 499 KB

english, 1996

5

Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

Wilko Weichert, Mathias Schmidt, Volker Gekeler, Carsten Denkert, Carsten Stephan, Klaus Jung, Stefan Loening, Manfred Dietel, Glen Kristiansen

Journal:

Year:

2004

Language:

english

File:

PDF, 244 KB

english, 2004

6

Reproducibility study of [18F]FPP(RGD)2uptake in murine models of human tumor xenografts

Edwin Chang, Shuangdong Liu, Gayatri Gowrishankar, Shahriar Yaghoubi, James Patrick Wedgeworth, Frederick Chin, Dietmar Berndorff, Volker Gekeler, Sanjiv S. Gambhir, Zhen Cheng

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2011

Language:

english

File:

PDF, 202 KB

english, 2011

7

In vivo assessment of subretinally implanted microphotodiode arrays in cats by optical coherence tomography and fluorescein angiography

Michael Völker, Kei Shinoda, Helmut Sachs, Helmut Gmeiner, Thorsten Schwarz, Konrad Kohler, Werner Inhoffen, Karl Ulrich Bartz-Schmidt, Eberhart Zrenner, Florian Gekeler

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2004

Language:

english

File:

PDF, 511 KB

english, 2004

8

Compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs

Florian Gekeler, Peter Szurman, Salvatore Grisanti, Ulrike Weiler, Rolf Claus, Tim-Oliver Greiner, Michael Völker, Konrad Kohler, Eberhart Zrenner, Karl Ulrich Bartz-Schmidt

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

9

Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

Wilko Weichert, Glen Kristiansen, Klaus-Jürgen Winzer, Mathias Schmidt, Volker Gekeler, Aurelia Noske, Berit-Maria Müller, Silvia Niesporek, Manfred Dietel, Carsten Denkert

Journal:

Virchows Archiv

Year:

2005

Language:

english

File:

PDF, 274 KB

english, 2005

10

Anticancer Drug-mediated Induction of Multidrug Resistance-associated Genes and Protein Kinase C Isozymes in the T-Lymphoblastoid Cell Line CCRF-CEM and in Blasts from Patients with Acute Lymphoblastic Leukemias

James F. Beck, Dorothee Brügger, Klaus Brischwein, Chao Liu, Peter Bader, Dietrich Niethammer, Volker Gekeler

Journal:

Year:

2001

Language:

english

File:

PDF, 241 KB

english, 2001

11

Expression patterns of polo-like kinase 1 in human gastric cancer

Wilko Weichert, Andrea Ullrich, Mathias Schmidt, Volker Gekeler, Aurelia Noske, Silvia Niesporek, Ann-Christin Buckendahl, Manfred Dietel, Carsten Denkert

Journal:

Year:

2006

Language:

english

File:

PDF, 188 KB

english, 2006

12

Assessment of the posterior segment of the cat eye by optical coherence tomography (OCT)

Florian Gekeler, Helmut Gmeiner, Michael Völker, Helmut Sachs, Andre Messias, Corinna Eule, Karl Ulrich Bartz-Schmidt, Eberhart Zrenner, Kei Shinoda

Journal:

Veterinary Ophthalmology

Year:

2007

Language:

english

File:

PDF, 266 KB

english, 2007

13

Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation

Florian Gantner, Christine Götz, Volker Gekeler, Christian Schudt, Albrecht Wendel, Armin Hatzelmann

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 336 KB

english, 1998

14

Dexniguldipine-HCl is a potent allosteric inhibitor of [3H]vinblastine binding to P-glycoprotein of CCRF ADR 5000 cells

Joy Malkhandi, David R. Ferry, Rainer Boer, Volker Gekeler, Wolfgang Ise, David J. Keer

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 928 KB

english, 1994

15

A novel method for direct and fluorescence independent determination of drug efflux out of leukemic blast cells

Markus Schaich, Stefan Neu, James Beck, Volker Gekeler, Ulrich Schuler, Gerhard Ehninger

Journal:

Leukemia Research

Year:

1997

Language:

english

File:

PDF, 1.20 MB

english, 1997

16

A novel method for direct and flourescence independent determination of drug efflux out of leukemic blast cells

Markus Schaich, Stefan Neu, James Beck, Volker Gekeler, Ulrich Schuler, Gerhard Ehninger

Journal:

Leukemia Research

Year:

1998

Language:

english

File:

PDF, 56 KB

english, 1998

17

Expression of mdrl, mrp, topoisomerase IIα/β, and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias

James Beck, Rupert Handgretinger, Roland Dopfer, Thomas Klingebiel, Dietrich Niethammer, Volker Gekeler

Journal:

British Journal of Haematology

Year:

1995

Language:

english

File:

PDF, 775 KB

english, 1995

18

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

Florian R Fritzsche, Wilko Weichert, Annika Röske, Volker Gekeler, Thomas Beckers, Carsten Stephan, Klaus Jung, Katharina Scholman, Carsten Denkert, Manfred Dietel, Glen Kristiansen

Journal:

Year:

2008

Language:

english

File:

PDF, 1.80 MB

english, 2008

19

Reversible shutdown of replicon initiation by transient hypoxia in Ehrlich ascites cells : Dependence of initiation on short-lived protein

Hans-Jörg RIEDINGER, Volker GEKELER, Hans PROBST

Journal:

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

20

Early electroretinographic features of streptozotocin-induced diabetic retinopathy

Kei Shinoda, Robert Rejdak, Frank Schuettauf, Georgios Blatsios, Michael Völker, Naoyuki Tanimoto, Tatar Olcay, Florian Gekeler, Cristina Lehaci, Rita Naskar, Zbigniew Zagorski, Eberhart Zrenner

Journal:

Clinical & Experimental Ophthalmology

Year:

2007

Language:

english

File:

PDF, 415 KB

english, 2007

21

G3139 and Other CpG-Containing Immunostimulatory Phosphorothioate Oligodeoxynucleotides Are Potent Suppressors of the Growth of Human Tumor Xenografts in Nude Mice

Gekeler, Volker, Gimmnich, Petra, Hofmann, Hans-Peter, Grebe, Carola, Römmele, Michaela, Leja, Astrid, Baudler, Monika, Benimetskaya, Luba, Gonser, Barbara, Pieles, Uwe

Journal:

Oligonucleotides

Year:

2006

Language:

english

File:

PDF, 423 KB

english, 2006

22

Replicon initiation frequency and intracellular levels of ATP, ADP, AMP and of diadenosine 5′,5‴-P1,P4-tetraphosphate in Ehrlich ascites cells cultured aerobically and anaerobically

Hans Probst, Klaus Hamprecht, Volker Gekeler

Journal:

Biochemical and Biophysical Research Communications

Year:

1983

Language:

english

File:

PDF, 403 KB

english, 1983

23

Oxygen dependent regulation of mammalian ribonucleotide reductase in vivo and possible significance for replicon initiation

Hans Probst, Helmut Schiffer, Volker Gekeler, Klaus Scheffler

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 499 KB

english, 1989

24

Mdr1P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles

Volker Gekeler, Stefan Weger, Hans Probst

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 658 KB

english, 1990

25

Mechanism of action of dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance

Johann Hofmann, Volker Gekeler, Wolfgang Ise, Andrea Noller, Jörg Mitterdorfer, Susanne Hofer, Irene Utz, Markus Gotwald, Rainer Boer, Hartmut Glossmann, Hans H. Grunicke

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 827 KB

english, 1995

26

Interaction of cytostatics and chemosensitizers with the dexniguldipine binding site on P-glycoprotein

Rainer Boer, Wolf-Rüdiger Ulrich, Sabine Haas, Christoph Borchers, Volker Gekeler, Hildegard Boss, Michael Przybylski, Angelika Schödl

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 876 KB

english, 1996

27

Synchronization of replicons in Ehrlich ascites cells

Volker Gekeler, Hans Probst

Journal:

Experimental Cell Research

Year:

1988

Language:

english

File:

PDF, 793 KB

english, 1988

28

No significant overreplication occurs in Ehrlich ascites cells during and after reversal of hypoxia

Hans Probst, Hans-Jörg Riedinger, Volker Gekeler

Journal:

Experimental Cell Research

Year:

1989

Language:

english

File:

PDF, 520 KB

english, 1989

29

Staurosporine suppresses replicon initiation in mammalian cells

Volker Gekeler, Annette Wilisch, Gudrun Probst, Andrea Kugel, Klaus Brischwein, Michael Engelcke, Hans Probst

Journal:

Year:

1993

Language:

english

File:

PDF, 761 KB

english, 1993

30

Rhodamine 123-efflux from hematopoietic subpopulations and leukaemic blast populations marked by PerCP-conjugated monoclonal antibodies

James Beck, Volker Gekeler, Martin Ringger, Rupert Handgretinger, Dietrich Niethammer

Journal:

Year:

1996

Language:

english

File:

PDF, 807 KB

english, 1996

31

Down-regulation of protein kinase Cη by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel

Jürgen Sonnemann, Volker Gekeler, Katrin Ahlbrecht, Klaus Brischwein, Chao Liu, Peter Bader, Cornelia Müller, Dietrich Niethammer, James F Beck

Journal:

Year:

2004

Language:

english

File:

PDF, 244 KB

english, 2004

32

Expression of a P-glycoprotein gene is inducible in a multidrug resistant human leukemia cell line

Volker Gekeler, Gerd Frese, Heyke Diddens, Hans Probst

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 516 KB

english, 1988

33

Induction of IL-15 mRNA and Protein in A549 Cells by Pro-inflammatory Cytokines

Michael Stoeck, Wolfgang Kromer, Volker Gekeler

Journal:

Year:

1998

Language:

english

File:

PDF, 5.21 MB

english, 1998

34

Rhodamine 123 efflux modulation in the presence of low or high serum from CD56+ hematopoietic cells or CD34+ leukemic blasts by B9309-068, a newly designed pyridine derivative

James Friedrich Beck, Frank Buchholz, Wolf-Rüdiger Ulrich, Rainer Boer, Karl Heinrich Sanders, Dietrich Niethammer, Volker Gekeler

Journal:

Year:

1998

Language:

english

File:

PDF, 203 KB

english, 1998

35

Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis

Wilko Weichert, Annika Röske, Volker Gekeler, Thomas Beckers, Matthias PA Ebert, Matthias Pross, Manfred Dietel, Carsten Denkert, Christoph Röcken

Journal:

The Lancet Oncology

Year:

2008

Language:

english

File:

PDF, 326 KB

english, 2008

36

High mdrl- and mrp-, but low topoisomerase IIα-gene expression in B-cell chronic lymphocytic leukaemias

James Beck, Dietrich Niethammer, Volker Gekeler

Journal:

Year:

1994

Language:

english

File:

PDF, 788 KB

english, 1994

37

Targeting Plk1 for cancer therapy

Mathias Schmidt, Hans-Peter Hofmann, Karl Sanders, Volker Gekeler, Thomas Beckers

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 41 KB

english, 2006

38

Reversible inhibition of replicon initiation in Ehrlich ascites cells by anaerobiosis

Hans Probst, Volker Gekeler

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 300 KB

english, 1980

39

Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study☆☆☆★★★

Gantner, Florian, Tenor, Hermann, Gekeler, Volker, Schudt, Christian, Wendel, Albrecht, Hatzelmann, Armin

Journal:

Journal of Allergy and Clinical Immunology

Year:

1997

Language:

english

File:

PDF, 931 KB

english, 1997

40

Overexpression of polo-like kinase 1 is a common and early event in pancreatic cancer

Weichert, Wilko, Schmidt, Mathias, Jacob, Juliane, Gekeler, Volker, Langrehr, Jan, Neuhaus, Peter, Bahra, Marcus, Denkert, Carsten, Dietel, Manfred, Kristiansen, Glen

Journal:

Year:

2005

Language:

english

File:

PDF, 321 KB

english, 2005

41

Mdr1P-glycoprotein expression in natural killer (NK) cells enriched from peripheral or umbilical cord blood

Wilisch, Annette, Noller, Andrea, Handgretinger, Rupert, Weger, Stefan, Nüssler, Volkmar, Niethammer, Dietrich, Probst, Hans, Gekeler, Volker

Journal:

Year:

1993

Language:

english

File:

PDF, 1.46 MB

english, 1993

42

Corrigendum to “high mdr-1- and mrp-, but low topoisomerase IIα-gene expression in B-cell chronic lymphocytic leukaemias”

Beck, James, Niethammer, Dietrich, Gekeler, Volker

Journal:

Year:

1995

File:

PDF, 44 KB

1995

43

The Dihydropyridine Dexniguldipine Hydrochloride Inhibits Cleavage and Religation Reactions of Eukaryotic DNA Topoisomerase I †

Straub, Tobias, Boesenberg, Charlotte, Gekeler, Volker, Boege, Fritz

Journal:

Year:

1997

Language:

english

File:

PDF, 311 KB

english, 1997

44

Application of Hypoxia-Induced Shut Down of Replicon Initiation to the Analysis of Replication Intermediates in Ehrlich Ascites Cells

GEKELER, Volker, STROPP, Udo, PROBST, Hans

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1986

File:

PDF, 1.96 MB

1986

45

Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis

Weichert, Wilko, Gekeler, Volker, Denkert, Carsten, Dietel, Manfred, Hauptmann, Steffen

Journal:

International Journal of Oncology

Year:

2003

Language:

english

File:

PDF, 1.82 MB

english, 2003